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Genetic element
(GENE)
published: 04 May 2020
last updated: 08 May 2020
Nonstructural protein 1
EN
NS1
EN
Protein coding sequence
No
-
BCH-ORGA-SCBD-45782-7 Organism Influenza A virus (Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu)Viruses
EN
EN
EN
Nonstructural protein 1 (NS1) is an antagonist of the host cellular anti-viral dsRNA mediated responses and the activation of interferon genes. The protein also regulates gene expression by preventing the export of mRNA into the cytoplasm through the suppression of 3' processing of the pre-mRNA. Therefore, host cellular protein synthesis is turned off. Viral mRNAs are not affected as the viral polymerase produces the 3' poly(A) tail. Research has also suggested that NS1 induces nucleolar stress through epigenetic alterations of rDNA promoters.
EN
- Structure and Function of the Influenza A Virus Non-Structural Protein 1 [ English ]
- Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling.PDF [ English ]
- Non-structural protein 1 of H3N2 influenza A virus induces nucleolar stress via interaction with nucleolin.pdf [ English ]
- UniProtKB - Influenza A NS1 [ English ]
- The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection.pdf [ English ]
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