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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2020-11-19 14:41 UTC (austein.mcloughlin@cbd.int)
Date of publication
2020-11-19 14:41 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Bacillus thuringiensis - Bt, Bacillus, BACTU
Characteristics of the protein coding sequence
Biological function
CRY14Ab1 is a crystal protein from Bacillus thuringiensis related to the other crystal proteins CRY1A, CRY3A and CRY4A. Structurally, the protein contains three domains. The protein has been demonstrated to have nematicidal activity against Caenorhabditis elegans, Panagrellus redivivus, Nippostrongylus brasiliensis, Distolabrellus veechi, Meloidogyne spp. (root knot nematodes), Rotylenchulus reniformis (reniform nematode), Hopiolaimus spp. (Lance nematode), Pratylenchus spp. and Heterodera glycines (soybean cyst nematode). The protein is thought to act in the intestine of nematodes. During feeding assays with C. elegans, the symptoms included constriction and thinning of intestinal cells, shrinkage of the gut, vacuolization and a degenerative appearance. Due to its relation to other crystal proteins, it is thought that CRY14A may also have insecticidal properties as well.
Related trait(s) or use(s) in biotechnology

Records referencing this document (5)
5record(s) found
Country's Decision or any other Communication2 records
Modified Organism1 record
Risk Assessment2 records