The dsRNA sequence is homologous to a portion of Diabrotica
virgifera virgifera smooth septate junction 1 (SSJ1) mRNA. The
SSJ1 gene (a homologue of Drosophila melanogaster
snakeskin) encodes a membrane protein, which is required for the
proper barrier function of the epithelial lining of insect
intestines. Disrupting expression of this gene (via RNA
interference) leads to growth inhibition and mortality.