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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2021-06-28 20:38 UTC (austein.mcloughlin@cbd.int)
Date of publication
2021-06-28 20:38 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Envelope glycoprotein gp160
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Human immunodeficiency virus 1 - HIV-1
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Envelope glycoprotein gp160
Biological function
HIV-1 envelope glycoprotein gp160 is a pre-protein that is cleaved in the host Golgi to produce two proteins: gp120 and gp41.

Surface protein gp120 is the viral protein that binds the host CD4 receptor. Binding to CD4 causes a structural conformation change allowing for a high affinity binding site to be formed for CXCR4 and/or CCR5. The protein is often present as a trimer, has five variable domains and post-translational modifications (glycosylation to evade host immune recognition).

Transmembrane protein gp41 is associated with gp120 and makes up the 'stalk' the envelope spike. The protein is required for viral fusion with the host cell. The protein is roughly 345 amino acids in size with three domains: C-terminal cytoplasmic tail, transmembrane domain and extracellular domain (to associate with gp120).
Related trait(s) or use(s) in biotechnology

Records referencing this document (1)
1record(s) found
Modified Organism1 record