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Living Modified Organism (LMO)
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Herculex™ I Roundup Ready™ 2 maize
EN
TC1507 x NK603
DAS-Ø15Ø7-1 x MON-ØØ6Ø3-6
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OrganizationDow AgroSciences ()Phone:Fax:Email:
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OrganizationPioneer Hi-Bred International Inc. ()Private sector (business and industry)7100 NW 62nd Avenue PO Box 1000Johnston, Iowa
50131, United States of AmericaPhone: +1 515 535-3200,Fax:Email:Website: www.pioneer.com/,
This LMO is the result of a cross between LMOs DAS-Ø15Ø7-1 and MON-ØØ6Ø3-6.
The MON-ØØ6Ø3-6 line of maize was developed to allow the use of glyphosate, the active ingredient in the herbicide Roundup®, as a weed control option. NK603 contains a form of the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) that allows the plant to survive the otherwise lethal application of glyphosate.
Corn line DAS-Ø15Ø7-1 is modified with the insertion of the Cry1F gene from Bacillus thuringiensis to confer resistance to the European corn borer (Ostrinia nubilalis). A transformation cassette coding for phosphinothricin (PPT) herbicide tolerance, specifically glufosinate ammonium, was also inserted into the organism.
The MON-ØØ6Ø3-6 line of maize was developed to allow the use of glyphosate, the active ingredient in the herbicide Roundup®, as a weed control option. NK603 contains a form of the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) that allows the plant to survive the otherwise lethal application of glyphosate.
Corn line DAS-Ø15Ø7-1 is modified with the insertion of the Cry1F gene from Bacillus thuringiensis to confer resistance to the European corn borer (Ostrinia nubilalis). A transformation cassette coding for phosphinothricin (PPT) herbicide tolerance, specifically glufosinate ammonium, was also inserted into the organism.
The term “Recipient organism” refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas “Parental organisms” refers to those that were involved in cross breeding or cell fusion.
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BCH-ORGA-SCBD-246-6 Organism Zea mays (Maize, Corn, MAIZE)Crops
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BCH-LMO-SCBD-14841-13 Living Modified Organism DAS-Ø15Ø7-1 - Herculex™ I maizeResistance to diseases and pests (Insects, Lepidoptera (butterflies and moths)), Resistance to herbicides (Glufosinate)
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BCH-LMO-SCBD-14776-17 Living Modified Organism MON-ØØ6Ø3-6 - Roundup Ready™ maizeResistance to herbicides - Glyphosate
PHP8999 and PV-ZMGT32
EN
- Cross breeding
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Some of these genetic elements may be present as fragments or truncated
forms. Please see notes below, where applicable.
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BCH-GENE-SCBD-14987-8 Cry1F | Bacillus thuringiensis - Bt, Bacillus, BACTUProtein coding sequence | Resistance to diseases and pests (Insects, Lepidoptera (butterflies and moths))
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BCH-GENE-SCBD-15002-4 Phosphinothricin N-acetyltransferase geneProtein coding sequence | Resistance to herbicides (Glufosinate)
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BCH-GENE-SCBD-14979-7 5-enolpyruvylshikimate-3-phosphate synthase geneProtein coding sequence | Resistance to herbicides (Glyphosate)
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BCH-GENE-SCBD-100362-7 Ubiquitin gene promoter | (Maize, Corn)Promoter
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BCH-GENE-SCBD-100363-5 ORF25 PolyA Terminator sequenceTerminator
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BCH-GENE-SCBD-100287-7 CaMV 35S promoterPromoter
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BCH-GENE-SCBD-100290-6 CaMV 35S terminatorTerminator
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BCH-GENE-SCBD-100364-5 Rice actin 1 gene promoter | (Rice)Promoter
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BCH-GENE-SCBD-100355-6 Rice actin 1, intron | (Rice)Intron
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BCH-GENE-SCBD-100269-8 Nopaline Synthase Gene TerminatorTerminator
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BCH-GENE-SCBD-100366-6 CaMV Enhanced 35S promoterPromoter
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BCH-GENE-SCBD-100359-7 Hsp70 intron | (Maize, Corn)Intron
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BCH-GENE-SCBD-100365-6 Chloroplast transit peptide 2 | (Thale cress)Transit signal
Notes about the Other(s) sequence(s) specific to this LMO
DNA construct from TC1507:
P-ubiZM1 (1.98) >> cry1F (1.82) >> T-ORF25 (0.72)* | P-35S (0.55) >> pat (0.55) >> T-35s (0.2)
DNA construct from NK603:
P-Ract1 >> I-Ract1 >> TS-CTP2 >> cp4-epsps >> T-nos | spacer (217) | P-e35S >> I-Hsp70 >> TS-CTP2 >> cp4-epsps >> T-nos
Note: the symbols >> and << indicate the sense and anti-sense direction of transcription, respectively, between different elements (typically, promoter - coding sequence - terminator). If present, the symbol | indicates elements that may be cloned adjacently in a cassette but that presumably are not transcribed together. The numbers in parenthesis indicate the approximate length in Kb of each genetic element.
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* The EFSA document attached below indicates that the 3’ sequence from the Agrobacterium tumefaciens mannopine synthase gene was used as terminator of the cry1F gene.
DNA construct from TC1507:
P-ubiZM1 (1.98) >> cry1F (1.82) >> T-ORF25 (0.72)* | P-35S (0.55) >> pat (0.55) >> T-35s (0.2)
DNA construct from NK603:
P-Ract1 >> I-Ract1 >> TS-CTP2 >> cp4-epsps >> T-nos | spacer (217) | P-e35S >> I-Hsp70 >> TS-CTP2 >> cp4-epsps >> T-nos
Note: the symbols >> and << indicate the sense and anti-sense direction of transcription, respectively, between different elements (typically, promoter - coding sequence - terminator). If present, the symbol | indicates elements that may be cloned adjacently in a cassette but that presumably are not transcribed together. The numbers in parenthesis indicate the approximate length in Kb of each genetic element.
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* The EFSA document attached below indicates that the 3’ sequence from the Agrobacterium tumefaciens mannopine synthase gene was used as terminator of the cry1F gene.
- Food
- Feed
- Biofuel
- CERA GM Database ( English )
- OECD Biotrack Product Database: DAS-Ø15Ø7-1 x MON-ØØ6Ø3-6 ( English )
- EFSA (2005) Opinion of the Scientific Panel on Genetically Modified Organisms on an application (reference EFSA-GMO-NL-2004-02) for the placing on the market of insect-tolerant genetically modified maize 1507... ( English )
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