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Living Modified Organism (LMO)
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Insect-resistant cotton
EN
281-24-236
Yes
DAS-24236-5
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Organization:Dow AgroSciences ()Phone:Fax:Email:
The cotton line 281-24-236 was genetically engineered to resist attack from Lepidopteran insect pests such as the tobacco budworm, cotton bollworm, beet armyworm, and soybean looper. This insect resistance is conferred by the cry1F gene, originally isolated from the common soil bacterium Bacillus thuringiensis (Bt) var. aizawai.
EN
The term “Recipient organism” refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas “Parental organisms” refers to those that were involved in cross breeding or cell fusion.
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BCH-ORGA-SCBD-12080-6 Organism Gossypium hirsutum (Cotton)Crops
Line: ‘Germain’s Acala GC510’
EN
pAGM281
EN
- Agrobacterium-mediated DNA transfer
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0.610 kb
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1.990 kb
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0.550 kb
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0.730 kb
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3.450 kb
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0.610 kb
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Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
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BCH-GENE-SCBD-14987-8 Cry1F | Bacillus thuringiensis (Bt, Bacillus, BACTU)Protein coding sequence | Resistance to diseases and pests (Insects, Lepidoptera (butterflies and moths))
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BCH-GENE-SCBD-100362-7 Ubiquitin gene promoter | Zea mays (Maize, Corn, MAIZE)Promoter
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BCH-GENE-SCBD-103627-5 Ubiquitin Intron 1 | Zea mays (Maize, Corn, MAIZE)Intron
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BCH-GENE-SCBD-15002-4 Phosphinothricin N-acetyltransferase gene | Streptomyces viridochromogenes (STRVR)Protein coding sequence | Resistance to herbicides (Glufosinate)
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BCH-GENE-SCBD-100363-5 ORF25 PolyA Terminator sequence | Agrobacterium tumefaciens (Agrobacterium)Terminator
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BCH-GENE-SCBD-103900-3 4ocs∆Mas2' promoterPromoter
Lepidopteran-resistant cotton, with insect resistance conferred by the cry1F gene from the common soil bacterium Bacillus thuringiensis (Bt) var. aizawai.
Coding sequences of Cry1F and pat genes altered for optimal expression in plant cells. The Cry1F protoxin is a chimeric, full-length δ-endotoxin comprised of the core toxin of Cry1F from Bacillus thuringiensis var. aizawai strain PS81I and nontoxic portions of Cry1Ca3 and Cry1Ab1 proteins. Together, the portions of Cry1Ca3 and Cry1Ab1 that comprise the chimeric C-terminal domain are approximately those removed by alkaline proteases during the formation of the active Cry1F core toxin.
EN
Coding sequences of Cry1F and pat genes altered for optimal expression in plant cells. The Cry1F protoxin is a chimeric, full-length δ-endotoxin comprised of the core toxin of Cry1F from Bacillus thuringiensis var. aizawai strain PS81I and nontoxic portions of Cry1Ca3 and Cry1Ab1 proteins. Together, the portions of Cry1Ca3 and Cry1Ab1 that comprise the chimeric C-terminal domain are approximately those removed by alkaline proteases during the formation of the active Cry1F core toxin.
EN
- Fiber/textile
EN
The cry1F gene produces the insect control protein Cry1F, a delta-endotoxin, in the plant tissues. Cry proteins, of which Cry1F is only one, act by selectively binding to specific sites localized on the lining of the midgut of susceptible insect species. Following binding, pores are formed that disrupt midgut ion flow, causing gut paralysis and eventual death due to bacterial sepsis. Cry1F is insecticidal only when eaten by the larvae of lepidopteran insects (moths and butterflies), and its specificity of action is directly attributable to the presence of specific binding sites in the target insects. There are no binding sites for delta-endotoxins of B. thuringiensis on the surface of mammalian intestinal cells, therefore, livestock animals and humans are not susceptible to these proteins.
EN
- CERA GM Database [ English ]
- DAS-24236-5 - Dow.pdf [ English ]
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