Date of creation
2008-09-18 02:10 UTC (firstname.lastname@example.org)
Date of last update
2012-08-02 02:49 UTC (email@example.com)
Date of publication
2012-08-02 06:46 UTC (firstname.lastname@example.org)
Determination for the Safety Assessment of Corn MIR 604 for Direct
Use as Food, Feed and for Processing
Department of Agriculture
Elliptical Road, Diliman
SYN-IR6Ø4-5 - Agrisure™ RW Rootworm-Protected maize
Resistance to diseases and pests - Insects - Coleoptera (beetles) - Western corn rootworm (Diabrotica virgifera)
Selectable marker genes and reporter genes Show detection method(s)
- LMOs for direct use as feed
- LMOs for direct use as food
- LMOs for processing
Toxicity and allergenicity studies showed that both mCry3A and PMI
proteins are readily degradable in gastric conditions and have no
similarity to any known toxins or allergens. Toxicity studies
showed that mCry3A and PMI did not exhibit adverse effects on
laboratory animals. No significant adverse effects were noted on
key nutrients and major analytes.Potential toxicant (DIMBOA) has
been reported in maize leaves and roots but decline as the plants
grow and therefore not a risk concern.
The expression of mCry3A and pmi genes do not alter the basic maize
Corn MIR604 is as safe as its conventional counterpart and does not
pose any significant risk to animal and human health.
A biosafety permit for Corn MIR604 and all progenies derived from
crosses of the product with any conventionally-bred corn and corn
containing approved-biotech events for direct use as food, feed or
for processing was issued to Syngenta Philippines, Inc. Corn
MIR604 is found to be as safe as its conventional counterpart and
does not pose any significant risk to human and animal health.
Corn MIR604 is found to be as safe as its conventional counterpart
and does not pose any significant risk to human and animal health.
This application is not for propagation of Corn MIR604. This LMO
will be directly used for food, feed and processing.
Quantitative diagnostic lateral flow strips, ELISA and PCR for
routine quantitative and semi-quantitative detection of
transgenes. For higher sensitivity, real-time PCR.
Corn MIR604 is intended for direct use as food, feed and for
All relevant references submitted by the technology developer in
their application; other references requested by the Scientific and
Technical Review Panel (STRP) members and DA Regulatory Agencies
during the evaluation of this event
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