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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2008-12-11 11:33 UTC (manoela.miranda@cbd.int)
Date of last update
2012-06-29 19:09 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-06-29 19:09 UTC (dina.abdelhakim@cbd.int)

General information
Name of the gene or DNA sequence
Killer Protein 4
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Ustilago maydis virus H1
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Killer protein 4
Biological function
KP4 specifically inhibits voltage-gated calcium channels inhibiting cell growth and division by blocking calcium import.

The KP4 gene is derived from the genome of a double-stranded RNA virus (Ustilago Maydis Virus 4, UmV4, Totiviridae, Totivirus,, which is present in the tissue of certain fungal strains of corn smut (Ustilago maydis). Expression of the KP4 gene leads to the production of the KP4 (killer protein 4).

In Ustilago maydis cells KP4 leads to a reversible inhibition of hyphal growth, but does not kill off competing strains. It is expected that plants expressing the KP4 protein are less susceptible to damage caused by the phytopathogenic fungi Ustilago spec.
Related trait(s) or use(s) in biotechnology

Records referencing this document (4)
4record(s) found
Country's Decision or any other Communication1 record
Modified Organism2 records
Risk Assessment1 record