Bacteriophage P1 (Phage P1) | BCH-ORGA-SCBD-103068 | Organism | Biosafety Clearing-House

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Organism (ORGA)

published: 06 Feb 2012 last updated: 04 Sep 2012
Organism information
Bacteriophage P1
Kingdom Viruses
Phylum Vira
Class dsDNA viruses, no RNA stage
Order Caudovirales
Family Myoviridae
Genus P1-like viruses
Species Bacteriophage P1
  • Enterobacteria phage P1
  • Phage P1
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Viruses
Characteristics related to biosafety
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Bacteriophages, like bacteria, are very common in all natural environments and are directly related to the numbers of bacteria present. They are thus very common in soil and have shaped the evolution of bacteria.
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  • Research
Additional Information
P1 is a temperate bacteriophage (phage) that infects Escherichia coli and a some other bacteria. When undergoing a lysogenic cycle the phage genome exists as a plasmid in the bacterium unlike other phages that integrate into the host DNA. P1 has an icosahedral "head" containing the DNA attached to a contractile tail with six tail fibers.

The P1 phage has gained research interest because it can be used to create the P1-derived artificial chromosome cloning vector which can carry relatively large fragments of DNA. Also, P1 encodes a site-specific recombinase, Cre, that is widely used to carry out cell-specific or time-specific DNA recombination by flanking the target DNA with loxP sites.(see Cre-Lox recombination)
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Records referencing this document Show in search
Record type Field Record(s)
Genetic element Donor organism(s) 1