Erns coding sequence | Pestivirus A (BVDV-1) | BCH-GENE-SCBD-110714 | Genetic element | Biosafety Clearing-House

Loading...
  |  

Genetic element (GENE)

last updated: 01 Aug 2016
General information
Erns coding sequence
EN
CS-Erns-BVDV
EN
Protein coding sequence
No
Donor organism
EN
Characteristics of the protein coding sequence
Erns
EN
Erns is a glycoprotein found on the surface of the BVDV viron. In addition to being a virion protein, a proportion of Erns is secreted from infected cells into the extracellular environment as a consequence of it lacking a typical transmembrane anchor domain.

The biological significance of secreted Erns has not been determined. However, Erns has two defined activities. First, Erns has an RNase activity that shows a strong preference for single-stranded RNA (ssRNA). Second, Erns glycoproteins of both BVDV and a closely related pestivirus, classical swine fever virus (CSFV), have been shown to bind to cell surface glycosylaminoglycans through residues located close to their C termini.
EN
Additional Information
EN
Records referencing this document Show in search
Record type Field Record(s)
Loading...