Mpp75Aa1.1 | Brevibacillus laterosporus (BRELA) | BCH-GENE-SCBD-263044 | Genetic element | Biosafety Clearing-House

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Genetic element (GENE)
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last updated: 02 Feb 2023
General information
Mpp75Aa1.1
EN
  • Cry75Aa1
    EN
  • Etx/Mtx2-related pesticidal protein 75Aa1.1
    EN
CS-mpp75aa1_1-BRELA
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Protein coding sequence
Yes
Donor organism
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Characteristics of the protein coding sequence
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Insecticidal protein Mpp75Aa1.1 is a member of the ETX_MTX family of beta-pore forming proteins with insecticidal activity against Coleoptera. The protein interacts with putative membrane-associated binding partners on the midgut apical microvilli. The protein has a similar mode of action to Cry proteins (from Bacillus thuringiensis), in which the protein is ingested and proteolytically activated, before binding a receptor and oligomerizing in the membrane to form a pore, resulting in cell death. The cellular damage results in death of the insect. The protein differs from Bt toxins as it forms beta-barrel pores instead of alpha-helical transmembrane pores. The protein consists: Domain I, receptor binding region; and Domain II and III, involved in pore formation.
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Records referencing this document Show in search
Record type Field Record(s)
Living Modified Organism Introduced or modified genetic element(s) 1
Living Modified Organism Genetic elements construct 1