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Information Resource
Record information and status
Record ID
103406
Status
Published
Date of creation
2012-05-09 14:26 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-09 14:26 UTC (dina.abdelhakim@cbd.int)

General Information
Title
Evaluation of potential risks associated with recombination in transgenic plants expressing viral sequences
Author
Camilla Turturo, Arianna Friscina, Ste´phane Gaubert, Mireille Jacquemond, Jeremy R. Thompson and Mark Tepfer
Author’s contact information
Mark Tepfer
Email: tepfer@icgeb.org
Organization(s) involved in the publication of this resource
International Centre for Genetic Engineering and Biotechnology - Trieste Component (ICGEB)
AREA Science Park
Padriciano 99
Trieste
Italy, 34012
Phone:+39-040-37571
Fax:+39-040-226555
Email:icgeb@icgeb.org
Url:http://www.icgeb.trieste.it/
Language(s)
  • English
Publication date
2008
Subject
Summary, abstract or table of contents
Abstract:

Virus-resistant transgenic plants have been created primarily through the expression of viral sequences. It has been hypothesized that recombination between the viral transgene mRNA and the RNA of an infecting virus could generate novel viruses. As mRNA/viral RNA recombination can occur in virus-resistant transgenic plants, the key to testing this risk hypothesis is to compare the populations of recombinant viruses generated in transgenic and non-transgenic plants. This has been done with two cucumoviral systems, involving either two strains of cucumber mosaic virus (CMV), or CMV and the related tomato aspermy virus (TAV). Although the distribution of the sites of recombination in the CMV/CMV and TAV/CMV systems was quite different, equivalent populations of recombinant viruses were observed in both cases. These results constitute the first comparison of the populations of recombinants in transgenic and non transgenic plants, and suggest that there is little risk of emergence of recombinant viruses in these plants, other than those that could emerge in non-transgenic plants.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Yes
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
Identifier
DOI 10.1099/vir.0.83339-0 0008-3339
Publisher and its location
Society for General Microbiology
UK
Rights
© 2008 SGM
Format
9 page PDF
Source
Journal of General Virology
Keywords and any other relevant information
Citation: Journal of General Virology (2008), 89, 327-335