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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2006-06-12 10:23 UTC (kirsty.mclean.consultant@cbd.int)
Date of last update
2014-02-27 14:53 UTC (dina.abdelhakim@cbd.int)
Date of publication
2014-02-27 14:53 UTC (dina.abdelhakim@cbd.int)

General information
Name of the gene or DNA sequence
Alternate Genetic Element Name (synonyms)
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Bacillus thuringiensis - Bt, Bacillus, BACTU
Donor organism point of collection
Bacillus thuringiensis subsp. kumamotoensis; strain EG4691
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
Cry3Bb1 delta-endotoxin
Biological function
The cry3Bb1 gene, isolated from the soil bacterium Bacillus thuringiensis (Bt) subspecies kumamotoensis, produces the insect control protein Cry3Bb1, a delta-endotoxin. The Cry3Bb1 protein provides protection against the western corn rootworm (Diabrotica vigifera) and northern corn rootworm (Diabrotica barberi).
Related trait(s) or use(s) in biotechnology
Additional Information
Additional Information
Cry proteins, of which Cry3Bb1 is only one, act by selectively binding to specific sites localized on the lining of the midgut of susceptible insect species. Following binding, pores are formed that disrupt midgut ion flow, causing gut paralysis and eventual death due to bacterial sepsis. Cry3Bb1 is lethal only when eaten by the larvae of coleopteran insects (i.e., beetles), and its specificity of action is directly attributable to the presence of specific binding sites in the target insects.

Records referencing this document (427)
427record(s) found
Country's Decision or any other Communication171 records
Information Resource1 record
Modified Organism70 records
Organization2 records
Risk Assessment183 records