The introduced lepidoptera resistance trait in GHB119 cotton is
conferred by the insecticidal crystal protein, Cry2Ae, encoded by
the cry2Ae gene, from the common soil bacterium, Bacillus
thuringiensis subsp. dakota (B.t. dakota). The Cry2Ae protein is
effective in controlling lepidopteran plant feeding larvae such as
cotton bollworm larvae (CBW, Helicoverpa zea), tobacco budworm
larvae (TBW, Heliothis virescens) and fall armyworm larvae (FAW,
Spodoptera frugiperda), which are common pests of cotton.
The herbicide tolerance trait (OECD, 1999 M-204493-01-1) is based
upon the bar gene, a bialaphos resistance gene, isolated from the
soil microorganism, Streptomyces hygroscopicus. The bar gene, when
expressed, enables the production of the enzyme,
Phosphinothricin-Acetyl-Transferase (PAT) that acetylates
L-glufosinate ammonium and thereby confers tolerance to herbicides
based upon glufosinate ammonium.