Loading...
العنصر الجيني (GENE)
 
last updated: ٢٦ آب أغسطس ٢٠٢٦
معلومات عامة
Modified head involution defective Ala2
EN
  • Lucilia sericata head involution defective Ala2
    EN
CS-hidAla2-LUCSE
EN
تسلسل شفرة البروتين
نعم
الكائن المانح
  • BCH-ORGA-SCBD-300803-2 الكائن الحي Lucilia sericata (Common greenbottle fly, Sheep-strike greenbottle fly, Common European greenbottle fly)
    الحشرات
AR
خصائص تسلسل ترميز البروتين
Modified Head involution defective (HID) protein
EN
The Lucilia sericata head involution defective Ala2 encodes a modified version of the Head Involution Defective (HID) protein, a pro-apoptotic factor that promotes programmed cell death (apoptosis). HID proteins promote cell death by antagonizing endogenous inhibitors of apoptosis, thereby facilitating activation of apoptotic pathways. The Ala2 variant was engineered by replacing two conserved mitogen-activated protein kinase (MAPK) phosphorylation sites with alanine residues. These substitutions were introduced to prevent phosphorylation-mediated inhibition of HID activity and enhance its effectiveness as a pro-apoptotic lethal effector.
EN