CP4 EPSPS has a low likelihood of adverse effects based on an assessment of its allergenic and toxicological potential.  The donor organism for CP4 EPSPS, Agrobacterium sp. strain CP4 is not known to cause human pathogenicity or allergenicity.  The results of bioinformatics analyses indicate that CP4 EPSPS is not similar to known allergens, toxins or other pharmacologically active proteins relevant to animal or human health,  CP4 EPSPS is rapidly digested in simulated digestive tract matrices. Absence of both structural and immunological similarities of CP4 EPSPS with known allergens indicate that CP4 EPSPS is unlikely to be an allergen.
CP4 EPSPS produced no adverse effects at a high dose in an acute oral rodent toxicity study.  The NOEL was found to be 572 mg/kg, the highest dose level tested.  
These results show that the CP4 EPSPS protein produced in NK603 will not cause adverse effects to human and animal health.
Glyphosate residue analysis of soil, corn grain and stover indicated that glyphosate applications did not produce any detectable level, thus lending support to worldwide reports on safety form the ecological standpoint. Glyphosate breakdown (through microbial action) does not produce secondary metabolites that can accumulate in the soil, thus repeated application for the chemical season after season will not pose a risk. Glyphosate has no adverse effects on soil, aquatic life, ecology and wildlife.