The stacked cotton line ACS-GHØØ1-3 x MON-15985-7 expresses three novel proteins: the enzyme phosphinothricin acetyl-transferase (PAT) and the delta-endotoxins Cry1Ac and Cry2Ab, both of which confer resistance to the lepidopteran pests of cotton, such as the cotton bollworm, pink bollworm and tobacco budworm.

The insecticidal proteins Cry1Ac and Cry2Ab are produced by the cry1Ac and cry2Ab genes respectively, both of which were originally isolated from the soil bacterium Bacillus thuringiensis and are derived from MON-15985-7. The bar gene, which codes for the production of PAT, is derived from ACS-GHØØ1-3. This enzyme renders glufosinate ammonium inactive in the plant. The expression of the bar gene allows the plant to survive the otherwise lethal application of glufosinate ammonium. The bar gene was isolated from Streptomyces hygroscopius, a gram-positive soil bacterium. The novel traits of each parental line have been combined, through traditional plant breeding, to produce this new cotton line.

For a full description of each parental line please refer to the individual descriptions for the parent organisms.

This plant is a product of traditional plant breeding, and therefore is not automatically subject to regulation in all jurisdictions as are transgenic plants resulting from recombinant DNA technologies. Certain jurisdictions may request notification in advance of the release of a stacked hybrid, or may request information to conduct an environmental and food safety assessment.