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Record information and status
Record ID
Date of creation
2012-05-08 17:47 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-08 17:47 UTC (dina.abdelhakim@cbd.int)

General Information
Non-target organism risk assessment of MIR604 maize expressing mCry3A for control of corn rootworm
A. Raybould, D. Stacey, D. Vlachos, G. Graser, X. Li 2 and R. Joseph
Author’s contact information
Alan Raybould,
E-mail: alan.raybould@syngenta.com

Syngenta, Jealott's Hill International Research Centre
Bracknell, Berkshire RG426EY
  • English
Publication date
Summary, abstract or table of contents

Event MIR604 maize expresses a modified Cry3A protein (mCry3A), for control of corn rootworm. As part of the environmental safety assessment of MIR604 maize, risks to non-target organisms of mCry3A were assessed. The potential exposure of non-target organisms to mCry3A following cultivation of MIR604 maize was determined, and the hypothesis that such exposure is not harmful was tested. The hypothesis was tested rigorously by making worst-case or highly conservative assumptions about exposure, along with laboratory testing for hazards using species taxonomically related to the target pest and species expected to have high exposure to mCry3A, or both. Further rigour was introduced by study designs incorporating long exposures and measurements of sensitive endpoints. No adverse effects were observed in any study, and in most cases exposure to mCry3A in the study was higher than the worst-case expected exposure. In all cases, exposure in the study was higher than realistic, but still conservative, estimates of exposure. These results indicate minimal risk of MIR604 maize to non-target organisms.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
doi: 10.1111/j.1439-0418.2007.01200.x
Publisher and its location
Blackwell Verlag
© 2007 The Authors
9 page PDF
Journal of Applied Entomology
Keywords and any other relevant information
Key words: environmental safety, exposure, hazard, hypothesis testing, transgenic plants

Citation: J. Appl. Entomol. 131(6), 391-399 (2007)