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Record information and status
Record ID
Date of creation
2012-05-10 20:23 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-10 20:23 UTC (dina.abdelhakim@cbd.int)

General Information
Improving Nutritional Quality of Maize Proteins by Expressing Sense and Antisense Zein Genes
Shihshieh Huang, Whitney R. Adams, Qing Zhou, Kathleen P. Malloy, Dale A. Voyles, Jan Anthony, Alan L. Kriz and Michael H. Luethy
Author’s contact information
Shihshieh Huang
Email: shihshieh.huang@na1.monsanto.com

Mystic Research, Monsanto Company,
62 Maritime Drive, Mystic, Connecticut 06355

telephone (860) 572-5201;
fax (860) 572-5240;
  • English
Publication date
Summary, abstract or table of contents

The predominant proteins in maize grain are a family of alcohol-soluble prolamin storage proteins called zeins. They account for >50% of total seed proteins but are deficient in several essential amino acids. As a result, the corn grain is considered to be nutritionally poor for monogastric animals with respect to key essential amino acids, most notably lysine, tryptophan, and methionine. Thus, corn mutants with reduced levels of zeins, such as opaque-2 (o2), have been demonstrated to possess grain with improved nutritional quality characteristics. The o2 mutant has a superior amino acid composition and has been used through conventional breeding to develop Quality Protein Maize (QPM) for human and animal consumption in developing countries. With the understanding of molecular genetics of zeins and progress in biotechnology, an alternative approach to zein reduction is explored here. Through the targeted reduction of the 19-kDa α-zeins, increased levels of lysine, tryptophan, and methionine have been engineered in grain of transgenic hybrids. Currently, the agronomic properties and nutritional values of these transgenic lines are being evaluated.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 3. Risk assessment of living modified plants with tolerance to abiotic stress
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
DOI: 10.1021/jf0342223
Publisher and its location
American Chemical Society
© 2004 American Chemical Society
7 page PDF
Journal of Agricultural and food chemistry
Keywords and any other relevant information
Keywords: Zein reduction; high lysine; high tryptophan; quality trait; antisense; maize; nutritional quality

Citation: J. Agric. Food Chem., 2004, 52 (7), pp 1958-1964