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Record information and status
Record ID
Date of creation
2012-05-11 19:46 UTC (dina.abdelhakim@cbd.int)
Date of last update
2012-05-11 19:47 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-11 19:47 UTC (dina.abdelhakim@cbd.int)

General Information
Population genetics of autocidal control and strain replacement
Fred Gould and Paul Schliekelman
Author’s contact information
Fred Gould

Department of Entomology, North Carolina State University,
Raleigh,North Carolina 27695

email: Fred Gould@ncsu.edu
  • English
Publication date
Summary, abstract or table of contents

The concept that an insect species' genome could be altered in a manner that would result in the control of that species (i.e., autocidal control) or in the replacement of a pestiferous strain of the species with a more benign genotype was first proposed in the mid-twentieth century. A major research effort in population genetics and ecology followed and led to the development of a set of classical genetic control approaches that included use of sterile males, conditional lethal genes, translocations, compound chromosomes, and microbe-mediated infertility. Although there have been a number of major successes in application of classical genetic control, research in this area has declined in the past 20 years for technical and societal reasons. Recent advances in molecular biology and transgenesis research have renewed interest in genetically based control methods because these advances may remove some major technical problems that have constrained effective genetic manipulation of pest species. Population genetic analyses suggest that transgenic manipulations may enable development of strains that would be 10 to over 100 times more efficient than strains developed by classical methods. Some of the proposed molecular approaches to genetic control involve modifications of classical approaches such as conditional lethality, whereas others are novel. Experience from the classical era of genetic control research indicates that the population structure and population dynamics of the target population will determine which, if any, genetic control approaches would be appropriate for addressing a specific problem. As such, there continues to be a need for ongoing communication between scientists who are developing strains and those who study the native pest populations.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 5. Risk assessment of living modified mosquitoes species that act as vectors of human and animal diseases
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
doi: 10.1146/annurev.ento.49.061802.123344
Copyright © 2004 by Annual Reviews
25 page PDF
Annual Reviews Entomology
Keywords and any other relevant information
Key Words transposons, transformation, eradication, dynamics, sex ratio, sterile males

Citation: Annu. Rev. Entomol. 2004. 49:193-217