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Record information and status
Record ID
Date of creation
2012-05-11 20:49 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-11 20:49 UTC (dina.abdelhakim@cbd.int)

General Information
Gene drive systems in mosquitoes: rules of the road
James AA.
Author’s contact information
Department of Microbiology, University of California,
Irvine, CA 92697-3900, USA.

Email: aajames@uci.edu
  • English
Publication date
Summary, abstract or table of contents

Population replacement strategies for controlling transmission of mosquito-borne diseases call for the introgression of antipathogen effector genes into vector populations. It is anticipated that these genes, if present at high enough frequencies, will impede transmission of the target pathogens and result in reduced human morbidity and mortality. Recent laboratory successes in the development of virus- and protozoan-resistant mosquito strains make urgent research of gene drive systems capable of moving effector genes into wild populations. A systematic approach to developing safe and effective gene drive systems that includes defining the requirements of the system, identifying naturally occurring or synthetic genetic mechanisms for gene spread upon which drive systems can be based and the successful adaptation of a mechanism to a drive system, should mitigate concerns about using genetically engineered mosquitoes for disease control.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 5. Risk assessment of living modified mosquitoes species that act as vectors of human and animal diseases
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
  • Report / Review / Fact sheet / Notes
doi: 10.1016/j.pt.2004.11.004
Publisher and its location
Copyright © 2005, Elsevier
Trends in Parasitology
Keywords and any other relevant information
Citation: Trends in Parasitology, Volume 21, Issue 2, February 2005, Pages 64-67
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