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Record information and status
Record ID
Date of creation
2012-05-14 13:22 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-14 13:22 UTC (dina.abdelhakim@cbd.int)

General Information
Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges
Michael A. Riehle, Prakash Srinivasan, Cristina K. Moreira and Marcelo Jacobs-Lorena
Author’s contact information
Marcelo Jacobs-Lorena

Johns Hopkins University, Bloomberg School of Public Health, Dept of Molecular Microbiology & Immunology,
615 N. Wolfe St, Baltimore, MO 21205-2179, USA

E-mail: mlorena@jhsph.edu
  • English
Publication date
Summary, abstract or table of contents

Malaria kills millions of people every year, yet there has been little progress in controlling this disease. For transmission to occur, the malaria parasite has to complete a complex developmental cycle in the mosquito. The mosquito is therefore a potential weak link in malaria transmission, and generating mosquito populations that are refractory to the parasite is a potential means of controlling the disease. There has been considerable progress over the last decade towards developing the tools for creating a refractory mosquito. Accomplishments include germline transformation of several important mosquito vectors, the completed genomes of the mosquito Anopheles gambiae and the malaria parasite Plasmodium falciparum, and the identification of promoters and effector genes that confer resistance in the mosquito. These tools have provided researchers with the ability to engineer a refractory mosquito vector, but there are fundamental gaps in our knowledge of how to transfer this technology safely and effectively into field populations. This review considers strategies for interfering with Plasmodium development in the mosquito, together with issues related to the transfer of laboratory-acquired knowledge to the field, such as minimization of transgene fitness load to the mosquito, driving genes through populations, avoiding the selection of resistant strains, and how to produce and release populations of males only.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
  • 5. Risk assessment of living modified mosquitoes species that act as vectors of human and animal diseases
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
  • Report / Review / Fact sheet / Notes
Publisher and its location
The Company of Biologists Ltd
© 2003 The Company of Biologists Ltd
8 page PDF
The Journal of Experimental Biology
Keywords and any other relevant information
Key words: Plasmodium, genetic engineering, paratransgenesis, genetic drive mechanisms, genetic sexing, fitness, mosquito.

Citation: The Journal of Experimental Biology 206, 3809-3816