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Record information and status
Record ID
Date of creation
2013-03-21 22:32 UTC (jack.heinemann@canterbury.ac.nz)
Date of last update
2013-03-22 15:29 UTC (jack.heinemann@canterbury.ac.nz)
Date of publication
2013-05-13 06:19 UTC (helmut.gaugitsch@umweltbundesamt.at)

General Information
A comparative evaluation of the regulation of GM crops or products containing dsRNA and suggested improvements to risk assessments
Heinemann, J.A., Agapito-Tenfen, S.Z., Carman, J.A.
Author’s contact information
Centre for Integrated Research in Biosafety
School of Biological Sciences
University of Canterbury
Christchurch, New Zealand 8142
+64 3 364 2500 (voice)
Organization(s) involved in the publication of this resource
University of Canterbury (UoC)
Private Bag 4800
New Zealand, 8041
Phone:+64 3 364 2500
  • English
Publication date
Summary, abstract or table of contents

Changing the nature, kind and quantity of particular regulatory-RNA molecules through genetic engineering can create biosafety risks. While some genetically modified organisms (GMOs) are intended to produce new regulatory-RNA molecules, these may also arise in other GMOs not intended to express them. To characterise, assess and then mitigate the potential adverse effects arising from changes to RNA requires changing current approaches to food or environmental risk assessments of GMOs. We document risk assessment advice offered to government regulators in Australia, New Zealand and Brazil during official risk evaluations of GM plants for use as human food or for release into the environment (whether for field trials or commercial release), how the regulator considered those risks, and what that experience teaches us about the GMO risk assessment framework. We also suggest improvements to the process.
Thematic areas
  • Biosafety policy and regulation
    • National/Domestic regulatory frameworks or guidelines
    • National decision making system
  • LMO use and transboundary movement
    • LMOs for use as food or feed or for processing
    • LMOs for introduction into the environment (Environmental releases)
    • LMOs for pharmaceuticals
  • Scientific and technical issues
    • Risk assessment
    • Risk management
    • Food and feed safety
    • Human health
    • Environmental Monitoring
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
ISSN: 0160-4120
Publisher and its location
Copyright held by authors. Open access (free download) resource.
13 page PDF
Environment International; Volume 55, May 2013, Pages 43-55
Keywords and any other relevant information
Genetically modified organisms; RNAi; dsRNA; Gene silencing; Biosafety