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Record information and status
Record ID
Date of creation
2007-09-02 12:51 UTC (UNEP-GEF)
Date of last update
2012-05-09 18:51 UTC (dina.abdelhakim@cbd.int)
Date of publication
2012-05-09 18:51 UTC (dina.abdelhakim@cbd.int)

General Information
The Mutational Consequences of Plant Transformation
Latham, Jonathan R.; Wilson, Allison K.; Steinbrecher, Ricarda A.
Author’s contact information
Latham, Jonathan R
Bioscience Resource Project,
PO Box 66, Ledbury HR8 9AE, UK
  • English
Publication date
Summary, abstract or table of contents

Plant transformation is a genetic engineering tool for introducing transgenes into plant genomes. It is now being used for the breeding of commercial crops. A central feature of transformation is insertion of the transgene into plant chromosomal DNA. Transgene insertion is infrequently, if ever, a precise event. Mutations found at transgene insertion sites include deletions and rearrangements of host chromosomal DNA and introduction of superfluous DNA. Insertion sites introduced using Agrobacterium tumefaciens tend to have simpler structures but can be associated with extensive chromosomal rearrangements, while those of particle bombardment appear invariably to be associated with deletion and extensive scrambling of inserted and chromosomal DNA. Ancillary procedures associated with plant transformation, including tissue culture and infection with A tumefaciens, can also introduce mutations. These genome-wide mutations can number from hundreds to many thousands per diploid genome. Despite the fact that confidence in the safety and dependability of crop species rests significantly on their genetic integrity, the frequency of transformation-induced mutations and their importance as potential biosafety hazards are poorly understood.
Thematic areas
  • Scientific and technical issues
    • Risk assessment
Background material to the “Guidance on risk assessment of living modified organisms”
Is this document is recommend as background material for the “Guidance on Risk Assessment of Living Modified Organisms”
Section(s) of the “Guidance on Risk Assessment of Living Modified Organisms” this background material is relevant
Additional Information
Type of resource
  • Article (journal / magazine / newspaper)
  • Report / Review / Fact sheet / Notes
DOI 10.1155/JBB/2006/25376
Publisher and its location
Hindawi Publishing Corporation
© 2006 Jonathan R. Latham et al
Adobe Acrobat Reader, Paper (7 pages)
Journal of Biomedicine and Biotechnology
Keywords and any other relevant information
Keywords: risk assessment, plant transformation, LMO categories: Plants

Citation: Journal of Biomedicine and Biotechnology Volume 2006, Article ID 25376, Pages 1-7