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Genetic element
(GENE)
last updated: 30 Jan 2015
Modified melittin peptide coding sequence
EN
CS-MsrA1-SYNTH
EN
Protein coding sequence
Yes
Modified melittin peptide
EN
Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. It is water-soluble as a tetramer, but it spontaneously integrates into lipid bilayers and is thought to act as a cytolytic and channel-forming antimicrobial peptide.
EN
This modified MsrA1 peptide is a synthetic molecule designed through molecular modelling. It includes the eight N-terminal amino acids of cecropin A from Hyalophora cecropia (Northern Silkworm) caterpillars and the eighteen C-terminal amino acids of melittin from Apis mellifera (Western Honey Bee), as well as two additional positively-charged amino acid residues at the C-terminus of the molecule, and an additional Met-Ala-Leu-Glu-His sequence at the N-terminus of the molecule.
EN
- Melittin - Wikipedia [ English ]
- The Structure of Melittin [ English ]
- Melittin: a Membrane-active Peptide with Diverse Functions [ English ]
- The actions of melittin on membranes [ English ]
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