Pestivirus A (BVDV-1) | BCH-ORGA-SCBD-110658 | Organism | Biosafety Clearing-House

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Organism (ORGA)

published: 23 Jun 2016 last updated: 29 Jun 2020
Organism information
Pestivirus A
Kingdom Orthornavirae
Phylum Kitrinoviricota
Class Flasuviricetes
Order Amarillovirales
Family Flaviviridae
Genus Pestivirus
Species Pestivirus A
  • Bovine viral diarrhea virus 1
  • BVDV-1
    EN
Additional classification
Group IV ((+)ssRNA)
Viruses
Characteristics related to biosafety
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Bovine Viral Diarrhea (BVD) is a significant economic disease of cattle which is endemic in the majority of countries throughout the world. The causative agent, bovine viral diarrhea virus (BVDV) is a member of the Pestivirus genus of the family Flaviviridae.
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BVD infection results in a wide variety of clinical signs, due to its immunosuppressive effects, as well as having a direct effect on respiratory disease and fertility.

Following viral entry and contact with the mucosal lining of the mouth or nose, replication occurs in epithelial cells. BVDV replication has a predilection for the palatine tonsils, lymphoid tissues and epithelium of the oropharynx.

Phagocytes take up BVDV or virus-infected cells and transport them to peripheral lymphoid tissues; the virus can also spread systemically through the bloodstream. Viraemia occurs 2–4 days after exposure and virus isolation from serum or leukocytes is generally possible between 3–10 days post infection

During systemic spread the virus is able to gain entry into most tissues with a preference for lymphoid tissues. Neutralising antibodies can be detected from 10–14 days post infection with titres continuing to increase slowly for 8–10 weeks. After 2–3 weeks, antibodies effectively neutralise viral particles, promote clearance of virus and prevent seeding of target organs
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  • Vaccine
Additional Information
The virus genome is positive-strand RNA that is translated to form a single virus polyprotein, which, through cleavage by both host and virus proteases, gives rise to either 11 or 12 mature viral proteins (NH2-Npro-C-Erns-E1-E2-p7-NS2-NS3-NS4A-NS4B-NS5A-NS5B-COOH), dependent on the virus biotype
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Living Modified Organism Recipient Organism” or “Parental Organisms 1
Genetic element Donor organism(s) 2