Escherichia virus Lambda (Lambda phage, LAMBD) | BCH-ORGA-SCBD-111831 | Organism | Biosafety Clearing-House

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Organism (ORGA)

published: 03 Apr 2017 last updated: 29 Jun 2020
Organism information
Escherichia virus Lambda
Kingdom Heunggongvirae
Phylum Uroviricota
Class Caudoviricetes
Order Caudovirales
Family Siphoviridae
Genus Lambdavirus
Species Escherichia virus Lambda
  • Bacteriophage Lambda
  • Enterobacteria Phage Lambda
  • Coliphage Lambda
  • Lambda phage
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  • LAMBD
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Additional classification
I (dsDNA)
Viruses
Characteristics related to biosafety
Enterobacteria phage λ was discovered by Esther Lederberg in 1950.
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Enterobacteria phage λ is a bacterial virus that infects the bacterial species Escherichia coli. During infection, the phage particle recognizes and binds to its host, E. coli, causing DNA in the head of the phage to be ejected through the tail into the cytoplasm of the bacterial cell. Usually, a "lytic cycle" ensues, where the lambda DNA is replicated and new phage particles are produced within the cell. This is followed by cell lysis, releasing the cell contents, including virions that have been assembled, into the environment. However, under certain conditions, the phage DNA may integrate itself into the host cell chromosome in the lysogenic pathway. In this state, the λ DNA is called a prophage and stays resident within the host's genome without apparent harm to the host.
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  • Research
Additional Information
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