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Genetic element
(GENE)
last updated: 21 May 2019
Nonstructural protein 3
EN
NS3
EN
Protein coding sequence
No
-
BCH-ORGA-SCBD-114710-2 Organism Yellow fever virus (YFV 17D)Viruses
Yellow fever virus strain 17D
EN
EN
Nonstructural protein 3 (NS3) has three enzymatic functions: serine protease, NTPase, and RNA helicase. NS3, along with cofactor nonstructural protein 2B, catalyzes its own autocleavage and cleaves the viral polyprotein. NS3 also functions in viral genome replication as an RNA helicase, unwinding dsRNA in the 3' to 5' direction. Likely, NS3 is involved in viral assembly, potentially interacting with other nonstructural proteins, such as nonstructural protein 2A.
EN
EN
- Yellow Fever Virus NS3 Plays an Essential Role in Virus Assembly Independent of Its Known Enzymatic Functions.pdf [ English ]
- UniProtKB - YFV polyprotein [ English ]
- Interaction between the yellow fever virus nonstructural protein NS3 and the host protein Alix contributes to the release of infectious particles.pdf [ English ]
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Introduced or modified genetic element(s) | 1 | |
| Living Modified Organism | Genetic elements construct | 1 | |
