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Genetic element (GENE)
last updated: 19 Aug 2019
ATM protein kinaseEN
Protein coding sequence
ATAXIA-TELANGIECTASIA MUTATED (ATM) is a serine/threonine protein kinase that catalyzes the addition of a phosphate group to serine or threonine residues and is activated upon perception of genotoxic stresses (e.g. ionizing radiation). ATM primarily responds to double stranded DNA breaks. The kinase phosphorylates histone variant H2AX to form H2AXS139ph at double strand breaks. The protein becomes activated in response to stress-induced damage in somatic cells and DNA damage during meiosis. ATM has also been implicated in cellular responses to telomere dysfunction. ATM works synergistically with RUG3 during the DNA damage response.
ATM is a homologue of the human ATM protein that has been implicated in Ataxia–telangiectasia, a chromosome instability disorder.
- (Arabidopsis) DNA damage checkpoint kinase ATM regulates.pdf ( English )
- (Arabidopsis homologue) TAIR: Locus: AT3G48190 ( English )
- (Arabidopsis homologue) UniProtKB: ATM ( English )
- (Arabidopsis homologue) Arabidopsis ATM and ATR Kinases Prevent Propagation.pdf ( English )
- The Plant DNA Damage Response - Signaling Pathways Leading to Growth Inhibition and Putative Role in Response to Stress Conditions.pdf ( English )