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Genetic element
(GENE)
last updated: 09 Jan 2020
bleomycin binding protein
EN
-
bleomycin resistance proteinEN
ble
EN
Protein coding sequence
No
-
BCH-ORGA-SCBD-14930-5 Organism Escherichia coli (ECOLX)Bacteria
The resistance protein is encoded on the TN5 transposon.
EN
EN
The protein has a high-binding affinity for bleomycin, thus has the ability to sequester bleomycin and confer resistance.
EN
Bleomycin is a glycopeptide antibiotic prodcued by Streptomyces verticillus. Bleomycin is thought to complex with iron (ii) and/or iron (III) to induce the formation of reactive oxygen species, which causes DNA cleavage and inhibit DNA synthesis. Due to its toxicity, the compound is not used in medical treatment as an antibiotic. However, it is used in the clinical treatment of cancerous tumours.
EN
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Introduced or modified genetic element(s) | 1 | |
| Living Modified Organism | Genetic elements construct | 1 | |
