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Genetic element
(GENE)
last updated: 06 May 2020
Polymerase basic protein 1
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PB1
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Protein coding sequence
No
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BCH-ORGA-SCBD-45782-7 Organism Influenza A virus (Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu)Viruses
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Polymerase basic protein 1 (PB1) complexes with polymerase acidic protein (PA) and polymerase basic protein 2 to form an RNA-dependent RNA polymerase. Transcription of viral mRNA occurs through a mechanism termed cap snatching, where the 5' methylated end (10 to 15 nucleotides) of the host pre-mRNAs is cleaved by PA and used for viral transcription. PB1 comprises the catalytic core of the polymerase and is responsible for RNA synthesis activity. PB1 uses the short sequences cleaved by PA for priming and initiating RNA synthesis.
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- UniProtKB - Influenza PB1 [ English ]
- FluDB - PB1 [ English ]
- Influenza A Virus Polymerase- Structural Insights into Replication and Host Adaptation Mechanisms.pdf [ English ]
- Functional Analysis of Conserved Motifs in Influenza Virus PB1 Protein.PDF [ English ]
- Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability.pdf [ English ]
- InterPro - Influenza PB1 [ English ]
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Introduced or modified genetic element(s) | 1 | |
| Living Modified Organism | Genetic elements construct | 1 | |
