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Genetic element
(GENE)
last updated: 06 May 2020
Polymerase basic protein 2
EN
PB2
EN
Protein coding sequence
No
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BCH-ORGA-SCBD-45782-7 Organism Influenza A virus (Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu)Viruses
EN
EN
Polymerase basic protein 2 (PB2) complexes with polymerase basic protein 1 and polymerase acidic protein (PA) to form an RNA-dependent RNA polymerase complex. During transcription, PB2 binds the 5′,7-methylguanosine cap of the host pre-mRNA, which will be subsequently cleaved by PA. PB2 also inhibits type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signalling protein MAVS.
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Research has suggested that 627 position in the PB2 has been implicated in increased replication or virulence of avian influenza viruses in mammals and transmission among humans.
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- UniProtKB - PB2 [ English ]
- Influenza A Virus Polymerase- Structural Insights into Replication and Host Adaptation Mechanisms.pdf [ English ]
- Scoring amino acid mutation to predict pandemic risk of avian influenza virus.pdf [ English ]
- Amino Acid Substitutions in Polymerase Basic Protein 2 Gene Contribute to the Pathogenicity of the Novel A H7N9 Influenza Virus in Mammalian Hosts.pdf [ English ]
- The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.pdf [ English ]
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Introduced or modified genetic element(s) | 1 | |
| Living Modified Organism | Genetic elements construct | 1 | |
