Cry1B.868 | Bacillus thuringiensis (Bt, Bacillus, BACTU) | BCH-GENE-SCBD-258889 | Genetic element | Biosafety Clearing-House

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Genetic element (GENE)

last updated: 14 Jan 2022
General information
Cry1B.868
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  • CS-cry1B.868-SYNTH
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CS-cry1Be2_1Ca_1Ab3-SYNTH
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Protein coding sequence
Yes
Donor organism
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Characteristics of the protein coding sequence
Cry1B.868
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The synthetic Cry1B.868 protein comprises domain 1 (D1) and domain 2 from Cry1Be2 (M1 to I503), domain 3 from Cry1Ca1 (N468 to N633), and the C-terminal protoxin moiety (domains 4 to 7) from Cry1Ab3 (E626 to E1155). The protein binds different receptors compared to other commonly available Bt proteins, such as Cry1F, Cry1A.105, Cry2Ab and Vip3A, but continues to demonstrate a pore-forming mode of action. Thus, the protein causes mortality and developmental delay in susceptible Lepidoptera insects, such as fall armyworm. In assays using Cry1F-resistant fall armyworm colonies, the protein overcame the insect's Bt-resistance.
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Record type Field Record(s)
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