You are viewing a DELETED record.
This record information is displayed for reference purpose only and should be not used.
This document has been updated. This is not the latest published version. Click here to view the latest version of the record.
last updated: 28 Apr 2022
Adeno-associated dependoparvovirus A
|Species||Adeno-associated dependoparvovirus A|
- Adeno-associated virus 2
Adeno-associated virus 2EN
Adeno-associate viruses (AAV) are defective, only undergoing productive replication in cells that are co-infected with another DNA virus, most commonly an adenovirus, which modifies the host environment in multiple ways that are essential to enable the AAV life cycle; by themselves AAVs are not associated with any known pathology. Under certain conditions, for example in the presence of DNA damaging agents, limited AAV replication can also be detected in the absence of helper viruses. Co-infection with helper virus triggers a lytic cycle as do some agents which appropriately perturb host cells. Wild-type AAV integrates preferentially into human chromosome 19q13.3-qter; recombinant vectors lose this specificity and appear to integrate randomly, thereby posing a theoretical risk of insertional mutagenesis.
- Other (Pathogen)
Adeno-associated virus 2 is a naked, icosahedral (20 - 25 nm diameter), single-stranded DNA virus. The genome consists of a single chromosome of 4679 nucleotides, flanked terminal repeats of 145 nucleotides that terminate in 125 nucleotide T-shaped hairpins (homotelomeric). These inverted repeats facilitate the integration into the host genome. As such, they have been employed in recombinant vectors to insert transgenes into the host genome. Thus, they may have a role in gene therapy.
- NCBI GenBank - Adeno-associated virus 2, complete genome [ English ]
- UniProtKB - Taxonomy - Adeno-associated virus 2 (AAV-2) [ English ]
- NCBI Taxonomy Browser - adeno-associated virus 2 [ English ]
- ICTV - Genus: Dependoparvovirus [ English ]
- Standford University - Adeno-Associated Virus Fact Sheet [ English ]
- [PDF] Nucleotide sequence and organization of the adeno-associated virus 2 genome [ English ]