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Genetic element
(GENE)
last updated: 18 Feb 2025
Coumarin synthase
EN
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HXXXD-type acyl-transferase family proteinEN
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AT1G28680EN
CS-cosy-ARATH
EN
Protein coding sequence
No
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BCH-ORGA-SCBD-12098-4 Organism Arabidopsis thaliana (Thale cress, Mouse-ear cress, Arabidopsis, ARATH)Plants
EN
Coumain synthase
EN
Coumain synthase catalyses trans-cis isomerization and lactonization in the biosynthesis of coumarins. More specifically, the enzyme produces umbelliferone, esculetin and scopoletin from their respective o-hydroxycinnamoyl-CoA thioesters by two reaction steps — a trans–cis isomerization followed by a lactonization. The enzyme has an essential function in the biosynthesis of coumarins in organs that are shielded from light, such as roots. In biotechnological applications, the overexpression of the gene (in combination with feruloyl CoA ortho-hydroxylase 1) leads to altered monomer composition in lignin.
EN
EN
- UniProtKB - HXXXD-type acyl-transferase family protein (A0A1P8AT84_ARATH) [ English ]
- TAIR - Locus: AT1G28680 (COSY) [ English ]
- [Science Advances] Overexpression of the scopoletin biosynthetic pathway enhances lignocellulosic biomass processing [ English ]
- ThaleMine - AT1G28680 A. thaliana [ English ]
- [Nature Communications] Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY [ English ]
- [Nature Plants] COSY catalyses trans–cis isomerization and lactonization in the biosynthesis of coumarins [ English ]
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Introduced or modified genetic element(s) | 1 | |
| Living Modified Organism | Genetic elements construct | 1 | |
