Acetohydroxy acid synthase gene | BCH-GENE-SCBD-48073 | Genetic element | Biosafety Clearing-House

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Genetic element (GENE)

published: 09 Jan 2009 last updated: 05 May 2016
General information
Acetohydroxy acid synthase gene
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  • Acetolactate Synthase (ALS) gene
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CS-ahas-ARATH
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Protein coding sequence
No
Donor organism
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Characteristics of the protein coding sequence
Acetohydroxy acid synthase
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AHAS is an essential enzyme for many organisms as it catalyzes the first step in the biosynthesis of the branched-chain amino acids valine, isoleucine, and leucine.

A common mutant form of the ahas gene was isolated from a herbicide-resistant Arabidopsis thaliana which differs from the wild type gene by only a single base pair. A "G" to "A" point mutation results in a single amino acid substitution in which the serine residue at position 653 is replaced by asparagine (S653N)

Tests using the mutant isoform of the ahas gene showed that it confers tolerance to sulfonylurea herbicides in plants. The ahas mutant isoform may, therefore, be used as a selectable marker in transgenic plants. 
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Additional Information
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Records referencing this document Show in search
Record type Field Record(s)
Living Modified Organism Introduced or modified genetic element(s) 14
Living Modified Organism Genetic elements construct 10