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Genetic element
(GENE)
last updated: 13 Feb 2023
Glycoprotein galactosyltransferase alpha-1,3
EN
-
N-acetyllactosaminide alpha-1,3-galactosyltransferaseEN
CS-ggta1-PIG
EN
Protein coding sequence
No
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BCH-ORGA-SCBD-263110-1 Organism Sus scrofa domesticus (Domestic pig, Hog, Swine, PIG)Mammals
EN
N-acetyllactosaminide alpha-1,3-galactosyltransferase
EN
Glycoprotein galactosyltransferase alpha-1,3 is the enzyme responsible for the production of galactose-alpha-1,3-galactose, which is found on the cell surfaces of all mammals (except humans and certain non-human primates). The enzyme catalyzes the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide disaccharide borne by a glycoprotein or a glycolipid. It has a preference for glycosylating proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isogloboside 3.
EN
People who have Alpha-gal symdrome (AGS) are allergic to red meat (e.g. pork, lamb, beef, venison, rabbit) and products made from mammals (e.g. gelatin, milk, etc.). Upon exposure (ingestion), their bodies produce IgE antibodies against the alpha-gal epitopes. There is growing evidence that suggests that AGS develops following bites from certain tick species. Some ticks implicated are: Amblyomma americanum (USA), Ixodes holocyclus (Australia), Amblyomma americanum (USA), Ixodes ricinus (Europe), and Ixodes cajennense (Panama) are confirmed as culprits, and Ixodes nipponensis (Japan and Korea), Amblyomma sculptum (Brazil), Amblyomma variegatum (Ivory Coast) and Haemaphysalis longicornis (Japan).
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Introduced or modified genetic element(s) | 1 | |
| Living Modified Organism | AFFECTEDGENES | 1 | |
| Living Modified Organism | Genetic elements construct | 1 | |
