Loading...
This record has been deleted. Since it is linked to a published record, it is available here for reference purposes only.
Click here to view the deleted recordThis document has been updated. This is not the latest published version. Click here to view the latest version of the record.
Genetic element
(GENE)
last updated: 11 Jun 2026
Hemagglutinin esterase
EN
-
HE antigenEN
-
HE glycoproteinEN
-
fHEEN
-
Hemagglutinin esterase glycoproteinEN
CS-fHE-ISAV
EN
Protein coding sequence
No
-
BCH-ORGA-SCBD-299480-1 Organism Isavirus salaris (Infectious salmon anemia virus, ISAV, ISA virus, Salmon isavirus)Viruses
EN
Hemagglutinin esterase glycoprotein
EN
The hemagglutinin esterase glycoprotein mediates the initial attachment of the infectious salmon anemia virus to susceptible host cells through binding to 4-O-acetylated sialic acid receptors. Its esterase activity facilitates viral release and spread by cleaving receptor molecules from cell surfaces. The protein plays a critical role in viral infectivity, tissue tropism and pathogenesis. As the major surface antigen of infectious salmon anemia virus, it is also responsible for inducing neutralizing antibodies and protective immune responses in infected or vaccinated fish.
EN
The hemagglutinin esterase glycoprotein is the principal protective antigen of the infectious salmon anemia virus and is widely used in the development of prophylactic vaccines for Atlantic salmon and other salmonids. Expression of the hemagglutinin esterase gene in recombinant systems, including deoxyribonucleic acid vaccines, viral-vectored vaccines and plant-based expression platforms, is intended to induce protective immune responses against infection. As the primary antigenic determinant of the virus, the protein is also used in diagnostic assays and molecular epidemiology studies. Variations within the highly polymorphic region of the hemagglutinin esterase gene are used to classify virus strains and have been associated with differences in pathogenicity.
