The data and analyses on the potential for toxicity or allergenicity of the CP4 EPSPS or NPT II proteins support the conclusions that neither protein is derived from an allergenic or toxic food source nor exhibits the characteristics of known protein allergens. CP4 EPSPS does not exhibit sequence similarity with known toxins or allergens. Furthermore, the CP4 EPSPS and NPT II proteins are present in relatively low abundance in cottonseed and both have been demonstrated to be degraded in conditions that mimic human digestion.
PTII protein was shown to degrade rapidly under simulated mammalian digestive conditions and cause no deleterious effects when administered in an acute gavage mouse study. The safety of CP4EPSPS was evaluated by physical and functional characteristics.  The expressed protein is rapidly digested and is not toxic to acutely gavaged mice.
Refined cottonseed oil and cellulose from processed linters are the two components of cotton used in human foods. Refined oil is generally accepted as being devoid of protein. CP4 EPSPS protein was detected in raw linters but could not be detected in linters after the first processing step. (Sims et al 1996). From these data it can be concluded that the food products derived from glyphosate-tolerant cotton should pose no greater threat as a source of allergic reaction than food products from conventional cotton.
Analysis on fat, protein, moisture and ash  have shown that seed from Roundup ready cotton is compositionally equivalent to and as nutritious as, seed from the parental cotton variety and other commercial cotton varieties Analysis have shown also  that the levels of fatty from Roundup ready cotton were comparable to the parental cotton variety and other commercial cotton varieties.  
Levels of toxicant cyclopropenoid fatty acids were determined for cottonseed.  No significant differences were detected between Cotton 1445 and control.  Analysis have shown that he levels of natural toxicants and anti-nutrients form roundup ready cotton were comparable to the parental cotton variety and other commercial varieties.