Recombinant human lactoferrin coding sequence | Homo sapiens (HUMAN) | BCH-GENE-SCBD-108043 | Genetic element | Biosafety Clearing-House

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Genetic element (GENE)

last updated: 15 May 2015
General information
Recombinant human lactoferrin coding sequence
EN
CS-rhLF-HUMAN
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Protein coding sequence
No
Donor organism
EN
Characteristics of the protein coding sequence
Recombinant human lactoferrin
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Lactoferrin is an iron-binding glycoprotein of the transferrin family, first isolated from milk but also found in most exocrine secretions as well as in the secondary granules of neutrophils. The many reports on its antimicrobial and antiinflammatory activityin vitro identify lactoferrin as important in host defense against infection and excessive inflammation. Most if not all lactoferrin actions are mediated through iron sequestration and/or interaction with a large variety of ligands including microbial cell wall components and cellular receptors, through its highly positively charged N-terminus. Lactoferrin exerts its effects on glandular epithelia, secretions, mucosal surfaces as well as in the interstitium and vascular compartments where it has been postulated to participate in iron metabolism, disease defense, and modulation of inflammatory and immune responses.
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Additional Information
EN
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