Tyrosine suppressor tRNA gene | Escherichia coli (ECOLX) | BCH-GENE-SCBD-111873 | Genetic element | Biosafety Clearing-House

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BCH-GENE-SCBD-111873-2   |   PDF   |   Print   |  

Genetic element (GENE)

last updated: 16 May 2017
General information
Tyrosine suppressor tRNA gene
EN
CS-supF-ECOLX
EN
Protein coding sequence
No
Donor organism
EN
Characteristics of the protein coding sequence
SupF tyrosine suppressor tRNA gene
EN
A suppressor tRNA contains a mutation in the anticodon region that leads to its recognition and binding to a stop codon. This leads to the suppression of protein truncation resulting from a nonsense mutation. Therefore the suppressor tRNA will bind and incorporate its amino acid, instead of the regular release factor binding and causing termination, allowing translation to continue.

The Escherichia coli tyrosine suppressor tRNA incorporates tyrosine at the chain termination codon UAG, thereby suppressing this stop-codon. It has been utilized in several shuttle-vector plasmids.
EN
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