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Genetic element
(GENE)
last updated: 08 May 2020
Polymerase I terminator
EN
-
rDNA terminatorEN
-
Murine terminatorEN
T-polI
EN
Terminator
No
-
BCH-ORGA-SCBD-45740-4 Organism Mus musculus (Mouse, House mouse, MOUSE)Mammals
EN
Mouse polymerase I terminator contains the necessary sequences to end the transcription of rDNA. It is important to note that unlike protein-coding genes, which are transcribed by RNA polymerase II, rRNA transcripts do not have a polyadenylated tail. Polyadenylation of rRNA can signal for degradation. Thus, polymerase I promoter and terminator are used to produce viral genomes that do not require polyadenylated tails (e.g. the negative-sense RNA segments of the influenza genome). Mouse RNA Pol I terminator is often chosen as it generates precise 3' ends of transcripts, which is important for viral genomic RNA.
EN
- Unidirectional RNA polymerase I–polymerase II transcription system for the generation of influenza A virus from eight plasmids.pdf [ English ]
- Basic Mechanisms in RNA Polymerase I Transcription of the Ribosomal RNA Genes.pdf [ English ]
- The mouse ribosomal gene terminator consists of three functionally separable sequence elements.pdf [ English ]
- The mouse Pol I terminator is more efficient than the hepatitis delta virus ribozyme in generating influenza-virus-like RNAs with precise 3' ends.pdf [ English ]
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Introduced or modified genetic element(s) | 1 | |
| Living Modified Organism | Genetic elements construct | 1 | |
