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Genetic element (GENE)
last updated: 18 Jun 2020
Protein coding sequence
Rift Valley Fever Virus glycoproteins Gn and Gc are the major structural antigens found on the virion particle. Together the two proteins are present as heterodimers and form the icosahedral shell of the virion. In vitro Gn and Gc form virus-like particles and can induce immunity in animals. Baculovirus expression systems expressing only Gc results in highly pleiomorphic virus-like particles. Thus, for homogeneous virus particle surfaces, heterodimer expression (Gn) is required.EN
- A Glycoprotein Subunit Vaccine Elicits a Strong Rift Valley Fever Virus Neutralizing Antibody Response in Sheep.pdf [ English ]
- A Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Confers Full Protection against Rift Valley Fever Challenge in Sheep.pdf [ English ]
- Rift Valley Fever - Recent Insights into Pathogenesis and Prevention.pdf [ English ]
- GenBank: Rift Valley fever virus strain MP-12 segment M, complete sequence [ English ]