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A Review of the Environmental Safety of the Cry3Bb1 Protein (Mar 2014)

This document provides a comprehensive review of the information and data relevant to the environmental risk assessment of Cry3Bb1, a protein encoded by a gene isolated from Bacillus thuringiensis (Bt), and it presents a summary statement about the environmental safety of this protein when produced in genetically engineered (GE) maize (Zea mays) plants. All sources of information reviewed herein are publicly available and include dossiers presented to regulatory authorities, decision documents p ...

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bch-vlr-scbd-105459-2
Article, Magazine, Journal, Newspaper
26 Mar 2014

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A Review of the Environmental Safety of the Cry2Ab Protein (Jul 2013)

This document provides a comprehensive review of the information and data relevant to the environmental risk assessment of Cry2Ab, a protein encoded by genes isolated from Bacillus thuringiensis (Bt), and it presents a summary statement about the environmental safety of this protein when produced in genetically engineered (GE) cotton (Gossypium hirsutum) and maize (Zea mays) plants. All sources of information reviewed herein are publicly available and include dossiers presented to regulatory aut ...

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bch-vlr-scbd-104997-1
Article, Magazine, Journal, Newspaper
01 Aug 2013

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A Review of the Environmental Safety of the Cry1F Protein (May 2013)

This document provides a comprehensive review of the information and data relevant to the environmental risk assessment of Cry1F, a family of proteins encoded by genes isolated from Bacillus thuringiensis (Bt), and it presents a summary statement about the environmental safety of these proteins when produced in genetically engineered (GE) cotton (Gossypium hirsutum) and maize (Zea mays) plants. All sources of information reviewed herein are publicly available and include dossiers presented to re ...

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bch-vlr-scbd-104996-2
Article, Magazine, Journal, Newspaper
01 Aug 2013

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A Review of the Environmental Safety of the Cry34Ab1 and Cry35Ab1 Proteins (Feb 2013)

This document provides a comprehensive review of the information and data relevant to the environmental risk assessment of two proteins encoded by genes isolated from Bacillus thuringiensis, Cry 34Ab1 and Cry35Ab1, and presents a summary statement about the environmental safety of these proteins when produced in the genetically engineered (GE) maize event DAS-59122-7 (Zea mays, L.). All sources of information reviewed herein are publicly available and include dossiers presented to regulatory aut ...

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bch-vlr-scbd-104779-2
Article, Magazine, Journal, Newspaper
19 Mar 2013

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Surrogate Species Selection for Assessing Potential Adverse Environmental Impacts of Genetically Engineered Plants on Non-Target Organisms (Jan 2013)

Most regulatory authorities require that developers of genetically engineered insect-resistant crops evaluate the potential for these crops to have adverse impacts on organisms not intended to be controlled by the trait, referred to as non-target organisms (NTOs). Conducting NTO testing poses both conceptual and logistical challenges for researchers, and the challenges are likely to increase as these crops are considered for commercial planting in a growing number of new geographic locations. Th ...

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bch-vlr-scbd-104596-4
Conference paper, Conference proceedings
20 Feb 2013

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A Review of the Environmental Safety of Vip3Aa (Jul 2012)

In 1996, a novel 88 kDa protein with insecticidal properties was isolated from Bacillus thuringiensis (Bt). This protein was distinguishable from the well-studied Bt Cry proteins, differing by sequence homology and activity spectrum. In addition, the protein was secreted by the cells, rather than stored within the bacteria as crystals, and it was synthesized during the vegetative phase of bacterial growth. Subsequently, a family of related proteins with similar properties was identified, and the ...

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bch-vlr-scbd-103864-2
Article, Magazine, Journal, Newspaper
28 Aug 2012

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A review of the environmental safety of the Cry1Ab protein (Dec 2011)

This document provides a comprehensive review of information and data relevant to the environmental risk assessment of Cry1Ab and presents a summary statement about the environmental safety of this protein. All sources of information reviewed herein are publically available and include: dossiers presented to regulatory authorities; decision summaries prepared by regulatory authorities; peer reviewed literature; and product summaries prepared by product developers.

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bch-vlr-scbd-103162-7
Article, Magazine, Journal, Newspaper
03 Aug 2012

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A Review of the Environmental Safety of the Cry1Ac Protein (May 2010)

This document provides a comprehensive review of information and data relevant to the environmental risk assessment of Cry1Ac and presents a summary statement about the environmental safety of this protein. All sources of information reviewed herein were publically available and included: dossiers presented to regulatory authorities; decision summaries prepared by regulatory authorities; peer reviewed literature; and product summaries prepared by product developers.

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bch-vlr-scbd-103144-8
Article, Magazine, Journal, Newspaper
03 Aug 2012

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Problem formulation in the environmental risk assessment for genetically modified plants (Sep 2009)

Problem formulation is the first step in environmental risk assessment (ERA) where policy goals, scope, assessment endpoints, and methodology are distilled to an explicitly stated problem and approach for analysis. The consistency and utility of ERAs for genetically modified (GM) plants can be improved through rigorous problem formulation (PF), producing an analysis plan that describes relevant exposure scenarios and the potential consequences of these scenarios. A properly executed PF assures t ...

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bch-vlr-scbd-103145-6
Article, Magazine, Journal, Newspaper
25 May 2012

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A Review of the Environmental Safety of the CP4 EPSPS Protein (May 2010)

This document provides a comprehensive review of information and data relevant to the environmental risk assessment of the protein 5 enolpyruvylshikimate-3-phosphate synthase isolated from Agrobacterium sp. strain CP4 (CP4 EPSPS) and presents a summary statement about the environmental safety of this protein. All sources of information reviewed herein were publically available and included: dossiers presented to regulatory authorities; decision summaries prepared by regulatory authorities; peer ...

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bch-vlr-scbd-103135-7
Article, Magazine, Journal, Newspaper
25 May 2012

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Recommendations for the design of laboratory studies on non-target arthropods for risk assessment of genetically engineered plants (Oct 2010)

This paper provides recommendations on experimental design for early-tier laboratory studies used in risk assessments to evaluate potential adverse impacts of arthropod-resistant genetically engineered (GE) plants on non-target arthropods (NTAs). While we rely heavily on the currently used proteins from Bacillus thuringiensis (Bt) in this discussion, the concepts apply to other arthropod-active proteins. A risk may exist if the newly acquired trait of the GE plant has adverse effects on NTAs whe ...

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bch-vlr-scbd-103134-6
Article, Magazine, Journal, Newspaper
25 May 2012

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Problem Formulation for the Environmental Risk Assessment of RNAi Plants: Conference Proceedings (Jun 2011)

The application of RNA interference (RNAi) to produce genetically engineered crops with improved agronomic, nutritional, industrial, and food-processing traits is becoming increasingly common. As new products approach commercialization, it is timely to consider whether the approach currently applied to the environmental risk assessment (ERA) of genetically engineered crops expressing novel proteins remains appropriate for the ERA of genetically engineered plants utilizing RNAi approaches. This q ...

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bch-vlr-scbd-103133-6
Conference paper, Conference proceedings
25 May 2012

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Genetically modified crops and aquatic ecosystems: considerations for environmental risk assessment and non-target organism testing (Nov 2011)

Environmental risk assessments (ERA) support regulatory decisions for the commercial cultivation of genetically modified (GM) crops. The ERA for terrestrial agroecosystems is well-developed, whereas guidance for ERA of GM crops in aquatic ecosystems is not as well-defined. The purpose of this document is to demonstrate how comprehensive problem formulation can be used to develop a conceptual model and to identify potential exposure pathways, using Bacillus thuringiensis (Bt) maize as a case stud ...

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bch-vlr-scbd-103132-5
Article, Magazine, Journal, Newspaper
25 May 2012

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