Major immediate early promoter containing intron A | Human betaherpesvirus 5 (Human cytomegalovirus, HCMV, HHV-5) | BCH-GENE-SCBD-115609 | Genetic element | Biosafety Clearing-House

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Genetic element (GENE)

last updated: 16 Jun 2020
General information
Major immediate early promoter containing intron A
EN
  • LP
    EN
P-IE
EN
Promoter
No
Donor organism
EN
Additional Information
The  human cytomegalovirus immediate-early promoter containing intron A  promotes high levels of transcription in animal systems. The inclusion of intron further further enhances transcription compared to the immediate-early promoter alone (15 times higher; human embryonic kidney cells). This promoter-intron system has previously been deployed in vaccine research.

From Sridhar et al. (2008) the following portions are found within this sequence:
Regulatory sequence = 437 bp
Enhancer = 481 bp
Promoter = 62 bp
Exon A = 120 bp
Intron A = 824 bp
EN
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