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Genetic element
(GENE)
last updated: 16 Jun 2020
Major immediate early promoter containing intron A
EN
-
LPEN
P-IE
EN
Promoter
No
-
BCH-ORGA-SCBD-103748-4 Organism Cytomegalovirus humanbeta5 (Human cytomegalovirus, HCMV, HHV-5)Viruses
EN
The human cytomegalovirus immediate-early promoter containing intron A promotes high levels of transcription in animal systems. The inclusion of intron further further enhances transcription compared to the immediate-early promoter alone (15 times higher; human embryonic kidney cells). This promoter-intron system has previously been deployed in vaccine research.
From Sridhar et al. (2008) the following portions are found within this sequence:
Regulatory sequence = 437 bp
Enhancer = 481 bp
Promoter = 62 bp
Exon A = 120 bp
Intron A = 824 bp
EN
From Sridhar et al. (2008) the following portions are found within this sequence:
Regulatory sequence = 437 bp
Enhancer = 481 bp
Promoter = 62 bp
Exon A = 120 bp
Intron A = 824 bp
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Introduced or modified genetic element(s) | 2 | |
| Living Modified Organism | Genetic elements construct | 2 | |
