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Genetic element
(GENE)
last updated: 28 Apr 2022
Inverted terminal repeats
EN
O-itr-AAV2
EN
Other (Inverted terminal repeats)
No
-
BCH-ORGA-SCBD-260316-1 Organism Adeno-associated dependoparvovirus A (Adeno-associated virus 2)Viruses
EN
The inverted terminal repeats (ITR) of Adeno-associated dependoparvovirus A (Adeno-associated virus 2) facilitate the integration of a viral sequence into a host genome, rescue of pro-viral genome and serve as primers for AAV DNA replication. The ITR are 145 nucleotides in length. When used in recombinant vectors, the sequences randomly integrate into the host genome. Research has suggested that the ITR may also act as a promoter with transcriptional activity varying by cell type.
- Inverted Terminal Repeat Sequences Are Important for Intermolecular Recombination and Circularization of Adeno-Associated Virus Genomes [ English ]
- Adeno-Associated Virus Serotype-Specific Inverted Terminal Repeat Sequence Role in Vector Transgene Expression.pdf [ English ]
- Adeno-associated virus inverted terminal repeats stimulate gene editing.pdf [ English ]
- The Unusual Properties of the AAV Inverted Terminal Repeat.pdf [ English ]
- Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain [ English ]
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