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Genetic element
(GENE)
last updated: 23 Dec 2025
Aminolevulinic acid synthase
EN
-
CS-hem1-KOMPAEN
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Delta-ALA synthaseEN
-
ALASEN
CS-hem1-PICPA
EN
Protein coding sequence
No
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BCH-ORGA-SCBD-106439-4 Organism Komagataella pastoris (Yeast)Fungi
EN
Aminolevulinic acid synthase
EN
Aminolevulinic acid synthase is the rate-limiting enzyme for heme biosynthesis. Because oxidized forms of downstream tetrapyrrole intermediates (uroporphyrin III, coproporphyrin III, and protoporphyrin IX),exhibit cytotoxic photodynamic properties, cellular levels of this enzyme are tightly regulated. Consequently, aminolevulinic acid synthase is maintained at low abundance under normal conditions; however, when intracellular heme levels are reduced, its expression increases several-fold to restore heme homeostasis. The regulation of aminolevulinic acid synthase by heme thus represents a classical example of end-product feedback control.
EN
EN
| Record type | Field | Record(s) | |
|---|---|---|---|
| Living Modified Organism | Introduced or modified genetic element(s) | 1 | |
| Living Modified Organism | Genetic elements construct | 1 | |
