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Genetic element (GENE)
last updated: 16 Aug 2022
Acyl-acyl carrier protein thioesterase
EN
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Acyl-[acyl-carrier-protein] hydrolaseEN
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FatB4EN
CS-fatb4-CUPLA
EN
Protein coding sequence
No
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BCH-ORGA-SCBD-101361-3 Organism Cuphea lanceolata (Cigar Flower)Ornamentals
EN
Acyl-acyl carrier protein thioesterase ClFatB4
EN
Acyl-acyl carrier protein (Acyl-ACP) thioesterases (TE) hydrolyse the thioester ligation between the ACP (acyl carrier protein) and the synthesised acyl chain in fatty acid biosynthesis. Myristic and palmitic-[ACP] are substrates of the Cuphea lanceolata-derived enzyme which is encoded by the acyl-[ACP] thioesterase gene (ClFatB4). As a result of the formation of this enzyme the oil produced in the seeds of the genetically modified (GM) plants contains myristic acid (C14:0), and increased levels of palmitic acid (C16:0).
Myristic and palmitic acids, the fatty acids formed by this enzyme occur naturally in some plant oils used for human consumption (e.g. coconut oil). There is currently no evidence pointing at a toxic effect from either the enzyme or the new metabolic product.
When used in modern biotechnology the introduced acyl-[ACP] thiosterase is expected to catalyse a reaction similar to that of corresponding enzymes occuring naturally in the seeds of other (wild and cultivated) plant species.
EN
Myristic and palmitic acids, the fatty acids formed by this enzyme occur naturally in some plant oils used for human consumption (e.g. coconut oil). There is currently no evidence pointing at a toxic effect from either the enzyme or the new metabolic product.
When used in modern biotechnology the introduced acyl-[ACP] thiosterase is expected to catalyse a reaction similar to that of corresponding enzymes occuring naturally in the seeds of other (wild and cultivated) plant species.
EN
- Fatty acyl-(ACP) thioesterase type B [Cuphea lanceolata] - Genbank protein sequence [ English ]
- Identification of amino acid residues involved in substrate specificity of plant acyl-ACP thioesterases using a bioinformatics-guided approach [ English ]
- UniProtKB - Acyl-[acyl-carrier-protein] hydrolase - K9JH59_CUPLA [ English ]
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