Acyl-acyl carrier protein thioesterase | Cuphea lanceolata (Cigar Flower) | BCH-GENE-SCBD-101362 | Genetic element | Biosafety Clearing-House

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Genetic element (GENE)

 
last updated: 16 Aug 2022
General information
Acyl-acyl carrier protein thioesterase
EN
  • Acyl-[acyl-carrier-protein] hydrolase
    EN
  • FatB4
    EN
CS-fatb4-CUPLA
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Protein coding sequence
No
Donor organism
EN
Characteristics of the protein coding sequence
Acyl-acyl carrier protein thioesterase ClFatB4
EN
Acyl-acyl carrier protein (Acyl-ACP) thioesterases (TE) hydrolyse the thioester ligation between the ACP (acyl carrier protein) and the synthesised acyl chain in fatty acid biosynthesis. Myristic and palmitic-[ACP] are substrates of the Cuphea lanceolata-derived enzyme which is encoded by the acyl-[ACP] thioesterase gene (ClFatB4). As a result of the formation of this enzyme the oil produced in the seeds of the genetically modified (GM) plants contains myristic acid (C14:0), and increased levels of palmitic acid (C16:0).

Myristic and palmitic acids, the fatty acids formed by this enzyme occur naturally in some plant oils used for human consumption (e.g. coconut oil). There is currently no evidence pointing at a toxic effect from either the enzyme or the new metabolic product.

When used in modern biotechnology the introduced acyl-[ACP] thiosterase is expected to catalyse a reaction similar to that of corresponding enzymes occuring naturally in the seeds of other (wild and cultivated) plant species.
EN
Records referencing this document Show in search
Record type Field Record(s)
Living Modified Organism Introduced or modified genetic element(s) 2
Living Modified Organism Genetic elements construct 2