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Genetic element (GENE)
published: 25 Mar 2013
last updated: 03 Aug 2022
4-hydroxyphenylpyruvate dioxygenase
EN
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CS-hppdPfW336-PSEFLEN
CS-HPPD-PSEFL
EN
Protein coding sequence
No
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BCH-ORGA-SCBD-48835-4 Organism Pseudomonas fluorescens (PSEFL)Bacteria
Strain: A32
EN
4-hydroxyphenylpyruvate dioxygenase
EN
4-hydroxyphenylpyruvate dioxygenase (HPPD) catalyses the conversion of 4-hydroxyphenylpyruvate to homogentisate which is the aromatic precursor of tocopherol and plastoquinone, which are essential to the photosynthetic transport chain and antioxidative systems. This reaction involves decarboxylation, substituent migration and aromatic oxygenation in a single catalytic cycle.
To enhance the protein's tolerance against HPPD inhibitors a point mutation was introduced into the coding sequence such that a replacement of the amino acid glycine with a tryptophane at position 336 was introduced, as described by Boudec et al. (2001)
EN
To enhance the protein's tolerance against HPPD inhibitors a point mutation was introduced into the coding sequence such that a replacement of the amino acid glycine with a tryptophane at position 336 was introduced, as described by Boudec et al. (2001)
In plants inhibition of HPPD affects the formation of homogentisic acid, which is a key precursor for the biosynthesis of both tocopherols (vitamin E) and plastoquinone, a critical co-factor in the formation of carotenoids, which protect chlorophyll in plants from being destroyed by sunlight. If this happens,the plants turn white without deformation due to complete loss of chlorophyll, and the plant dies.
EN
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